Sudo scan
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Sudoscan results correlate significantly with clinical measures of neuropathy, somatic and autonomic function testing, and pain scores. Sudoscan is a sensitive tool to detect neuropathy in patients with DM
Sudoscan system helps clinicians with Peripheral Neuropathies and Sudomotor function evaluation. The assessment focuses on tiny nerve fibers within the autonomic nervous system, and their ability to quickly regenerate.
Small nerve fibers are the first victims of diabetes, which affects the peripheral nervous system even if symptoms remain sub-clinical. According to a recent study, already at an early stage of diabetes, the sympathetic innervation of sweat glands density and function is progressively reduced.
How Test is done:
Sudoscan has been created to enable a precise evaluation of sweat gland function. Based on a measuring method, patients place their hands and feet on stainless-steel electrodes. The method uses low voltage to stimulate the sweat glands and measure the electrochemical reaction between electrodes and chloride ions. This active, new method provides information and evidence of a sweat dysfunction that might otherwise not be detectable in physiological conditions.
The Sudoscan system represents a sympathetic skin response device that provides skin conductance measurements on a computer screen.
Sudoscan is, similar to a galvanic skin response stress test, a functional test that measures the sweat glands' capacity to release chloride ions following an electrochemical stimulation. It works by measuring the electrical potential difference caused by the electrochemical reaction of electrodes, which are applied to the skin and stimulated by a low voltage of variable amplitude. Sudoscan determines the cardiometabolic risk in patients.
Analytical Overview
- Small unmyelinated C-fibers are responsible for the function of sweat glands
- Sudomotor dysfunction has been established as one of the earliest detectable neurophysiologic abnormalities in distal small fiber neuropathies.
- A quantitative assessment of sweat response is an index of the severity and distribution of automatic failure. It will also serve as an early indicator for the regeneration of small fibers.
- Diabetic patients have been observed to experience a degeneration of small C-fiber innervating sweat glands.
- Measures bio electrochemical sweat skin conductance’s (BEC) are directly connected to the capability of the glands to transfer chloride ions and which reflects small-C fiber status.
- Sudoscan is a fast and easy method to measure sweat function
- 3 minutes or 6 minutes test options.
Advantages
- It does not require any patient preparation, such as blood drawing or fasting.
- Non-invasive and delivers immediate results, with findings within 3 minutes.
- It was developed for general practitioners, cardiologists, and neurologists to assist in the effective screening of cardiometabolic risk in patients.
- Evaluate patients with Diabetes Mellitus, as an instrument to assess autonomic neuropathy and neuropathic pain.
- Operates with a sensitivity of 80% and a specificity of 95%.
- Results suggest that the peripheral autonomic nervous system plays a role in painful diabetic neuropathy.
- Results correlated significantly with clinical neuropathy scores, pain scores and measures of autonomic dysfunction.
- Evaluate in patients with Diabetes Mellitusm, as an instrument to assess autonomic neuropathy and neuropathic pain.
- 3 minutes or 6 minutes test options.
- Sudoscan is an innovative, sensitive tool for the detection of diabetic neuropathy, especially painful diabetic neuropathy. As sweat glands are innervated by small c fibers, which are also involved in pain pathways, precise measuring of the sweat gland function can identify that cause.
Evaluation Of Sudomotor Function
Why evaluate sudomotor function?
The study of sudomotor presents a valuable tool to assess autonomic disorders. Sudomotor function is known to reflect sympathetic activity and provide insight into postganglionic autonomic innervation.
The need for a faster sudomotor function test
Evaluation of sudomotor function in diabetes
On of the significant causes of nerve damage is diabetes. Diabetic patients suffer from metabolic impairment and related inflammatory processes. As a result, their non-myelinated axons of small fiber nerves are primarily affected and known as Diabetic Autonomic Neuropathy (DAN).